Species: Dog
Condition: Organic Aciduria
Organ System: Nervous/sensory
Also called l-2-Hydroxyglutaric aciduria (l-2-HGA). This is a hereditary neuro-metabolic disorder which is characterized by abnormal changes in the brain, affecting the gray matter of the cerebellum, cerebral cortex, thalamus, and brain stem. It is caused by the increased concentration of L-2-Hydroxyglutaric acid in the cerebrospinal fluid, and in the blood plasma. Distinct symptoms reflect the progressive deterioration of the function of the central nervous system. Affected dogs suffer from epileptic seizures and may have an abnormally enlarged brain and head, called macrocephaly. Many cases of the disease have been described in Staffordshire bull terriers. Medications help control recurrent epileptic seizures.
Breeds exposed to Organic Aciduria – Research Reference
Labrador Retriever – (Van de Sandt et al. 2003)
Labrador Retriever Cross – (Van de Sandt et al. 2003)
“Cairn Terrier Cross – (Rubin 1989
Labradoodle Cross – (Van de Sandt et al. 2003)
Labrador Cross – (Van de Sandt et al. 2003)
“Cairn Terrier – (Rubin 1989
Labradoodle – (Van de Sandt et al. 2003)
Labrador – (Van de Sandt et al. 2003)
Disease Author
Dr Merliza Cabriles, Professor of Veterinary Medicine
To learn more about Organic Aciduria or any other condition we invite you to search this website. Even better, pick up the phone and call your vet. Your vet knows your pet better than anyone else and is a fountain of information.
This information is accurate as at May 2014 and is subject to change without notice.
For Petmed Pet Health Insurance – pre-existing condition exclusion applies. Annual Benefit Limits and excess amounts vary based on pet health insurance plans.
