Hypertrophic Neuropathy in dogs

Species: Dog
Condition: Hypertrophic Neuropathy
Organ System: Nervous/sensory

Also called canine inherited hypertrophic neuropathy, this congenital problem has been diagnosed in Tibetan Mastiff. Demyelination of the peripheral Schwann nerve cells results in the appearance of nervous signs. Affected dogs experience weakness in the hind limbs that usually manifests when the dog is between 6-14 months of age. With time, the weakness will spread to the front limbs. A dog may also suffer from decreased reflexes and may lose the ability to bark. Sensory function may still remain however, an abnormal gait may be quite distinct. There are dogs that may recover for several years however there is a higher possibility of recurrence.

Breeds exposed to Hypertrophic Neuropathy – Research Reference
Australian Shepherd Cross – (Wood et al. 1998)
Miniature Poodle Cross – University of Sydney (LIDA Dog Disease Database)
Boston Terrier Cross – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
Alsatian Cross – Canine Inherited Disorders Database (CIDD) & (Reusch & Feldman 1991)
German Shepherd Cross – (Reusch & Feldman 1991) & Canine Inherited Disorders Database (CIDD)
“Jack Russell Terrier Cross – (Peters
Miniature Dachshund Cross – University of Sydney (LIDA Dog Disease Database)
Dachshund Cross – Canine Inherited Disorders Database (CIDD) & (Scott & Anderson 1990)
Labradoodle Cross – (Alenza et al. 2006) & (Feldman & Nelson 1996)
German Spitz Cross – University of Sydney (LIDA Dog Disease Database)
PRESSA CANARIO CROSS – University of Sydney (LIDA Dog Disease Database)
Labrador Retriever Cross – (Feldman & Nelson 1996) & (Wood et al. 1998)
American Akita Cross – University of Sydney (LIDA Dog Disease Database)
Boxer Cross – University of Sydney (LIDA Dog Disease Database) & (Alenza et al. 2006)
Beagle Cross – (Feldman & Nelson 1996) & (Wood et al. 1998)
Rottweiler Cross – Canine Inherited Disorders Database (CIDD)
Poodle – Standard Cross – (Alenza et al. 2006) & (Reusch & Feldman 1991)
Akita Inu Cross – University of Sydney (LIDA Dog Disease Database)
American Eskimo Cross – University of Sydney (LIDA Dog Disease Database)
German Spitz – University of Sydney (LIDA Dog Disease Database)
Poodle – Toy Cross – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
“Staffordshire Bull Terrier Cross – (Peters
Scottish Terrier Cross – (Zeugswetter 2008)
West Highland White Terrier Cross – University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund – Wire Haired Cross – (Wood et al. 1998) & University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund- Long Haired Cross – (Wood et al. 1998) & University of Sydney (LIDA Dog Disease Database)
Schnoodle Cross – (Alenza et al. 2006) & (Reusch & Feldman 1991)
Yorkshire Terrier Cross – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
Shih Tzu Cross – (Wood et al. 1998)
Miniature Dachshund – Smooth Haired Cross – University of Sydney (LIDA Dog Disease Database)
Alsatian – Canine Inherited Disorders Database (CIDD) & (Reusch & Feldman 1991)
Poodle – Toy – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
Rottweiler – Canine Inherited Disorders Database (CIDD)
Yorkshire Terrier – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
Boston Terrier – Canine Inherited Disorders Database (CIDD) & University of Sydney (LIDA Dog Disease Database)
Dachshund – Canine Inherited Disorders Database (CIDD) & (Scott & Anderson 1990)
Dandie Dinmont Terrier – Canine Inherited Disorders Database (CIDD)
German Shepherd – Canine Inherited Disorders Database (CIDD) & (Reusch & Feldman 1991)
Japanese Akita – University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund – Wire Haired – University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund – Smooth Haired – University of Sydney (LIDA Dog Disease Database)
Akita Inu – University of Sydney (LIDA Dog Disease Database)
Keeshond – University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund – University of Sydney (LIDA Dog Disease Database)
West Highland White Terrier – University of Sydney (LIDA Dog Disease Database)
American Eskimo – University of Sydney (LIDA Dog Disease Database)
Boxer – University of Sydney (LIDA Dog Disease Database) & (Alenza et al. 2006)
Dachshund – Long Haired – University of Sydney (LIDA Dog Disease Database)
Miniature Poodle – University of Sydney (LIDA Dog Disease Database)
Miniature Dachshund- Long Haired – University of Sydney (LIDA Dog Disease Database)
American Akita – University of Sydney (LIDA Dog Disease Database)
Pressa Canario – University of Sydney (LIDA Dog Disease Database)
Cavoodle – University of Sydney (LIDA Dog Disease Database)
Labrador Cross – (Feldman & Nelson 1996) & (Wood et al. 1998)
Keeshond Cross – University of Sydney (LIDA Dog Disease Database)
Spoodle Cross – (Alenza et al. 2006) & (Wood et al. 1998)
Cocker Spaniel Cross – (Wood et al. 1998)
Labrador – (Feldman & Nelson 1996) & (Wood et al. 1998)
Poodle – Standard – (Alenza et al. 2006) & (Reusch & Feldman 1991)
Golden Doodle (Groodle) – (Alenza et al. 2006) & (Reusch & Feldman 1991)
Labradoodle – (Alenza et al. 2006) & (Feldman & Nelson 1996)
Schnoodle – (Alenza et al. 2006) & (Reusch & Feldman 1991)
Spoodle – (Alenza et al. 2006) & (Wood et al. 1998)
Beagle – (Feldman & Nelson 1996) & (Wood et al. 1998)
Labrador Retriever – (Feldman & Nelson 1996) & (Wood et al. 1998)
Scottish Terrier – (Zeugswetter 2008)
Australian Shepherd – (Wood et al. 1998)
Cocker Spaniel – (Wood et al. 1998)
Shih Tzu – (Wood et al. 1998)
“Jack Russell Terrier – (Peters
“Staffordshire Bull Terrier – (Peters
Dachshund – Long Haired Cross – University of Sydney (LIDA Dog Disease Database)
Japanese Akita Cross – University of Sydney (LIDA Dog Disease Database)
Dandie Dinmont Terrier Cross – Canine Inherited Disorders Database (CIDD)

Disease Author
Dr Merliza Cabriles, Professor of Veterinary Medicine

To learn more about Hypertrophic Neuropathy or any other condition we invite you to search this website. Even better, pick up the phone and call your vet. Your vet knows your pet better than anyone else and is a fountain of information.