Pyruvate Dehydrogenase Phosphatase 1 Deficiency in dogs

Species: Dog
Condition: Pyruvate Dehydrogenase Phosphatase 1 Deficiency
Organ System: Respiratory

Pyruvate Dehydrogenase Phosphate 1 Deficiency (PDP1) is a genetic deficiency which has been diagnosed in Clumber and Sussex spaniels. It is characterized by a lack of enzymes that results in failure of the PDH complex to get rid of the waste products of metabolism. Affected dogs suffer from extreme exhaustion and very poor exercise tolerance. There are cases when the dog recovers and walks normally again however these dogs have very poor tolerance to exercise. PDP1 can be a major predisposing factor of major heart and lung problems that can eventually lead to early death. Being carried by an autosomal recessive gene, a carrier must have mated with another carrier for their offspring to manifest signs of the disease.

Breeds exposed to Pyruvate Dehydrogenase Phosphatase 1 Deficiency – Research Reference
“German Shepherd Cross – (Nieves 2002
Basset Hound Cross – University of Sydney (LIDA Dog Disease Database)
“Alsatian Cross – (Nieves 2002
“Golden Retriever Cross – (LaFond
“Labradoodle Cross – University of Sydney (LIDA Dog Disease Database) & (Nieves 2002
“Labrador Retriever Cross – (Nieves 2002
“Boxer Cross – (Nieves 2002
“Rottweiler Cross – (Nielen et al. 2001
Neopolitan Mastiff Cross – University of Sydney (LIDA Dog Disease Database)
“St Bernard Cross – (Nielen et al. 2001
Deerhound Cross – University of Sydney (LIDA Dog Disease Database)
“Irish Setter Cross – (Nieves 2002
Irish Wolfhound Cross – University of Sydney (LIDA Dog Disease Database)
Wolfhound Cross – University of Sydney (LIDA Dog Disease Database)
Weimaraner Cross – University of Sydney (LIDA Dog Disease Database) & (Harrus et al. 2002)
Schnoodle Cross – University of Sydney (LIDA Dog Disease Database)
“Irish Red and White Setter Cross – (Nieves 2002
Schnauzer Giant Cross – University of Sydney (LIDA Dog Disease Database)
Deerhound – University of Sydney (LIDA Dog Disease Database)
“Great Dane – University of Sydney (LIDA Dog Disease Database) & (LaFond
Irish Wolfhound – University of Sydney (LIDA Dog Disease Database)
Neopolitan Mastiff – University of Sydney (LIDA Dog Disease Database)
Schnauzer Giant – University of Sydney (LIDA Dog Disease Database)
Tibetan Mastiff – University of Sydney (LIDA Dog Disease Database)
Weimaraner – University of Sydney (LIDA Dog Disease Database) & (Harrus et al. 2002)
Basset Hound – University of Sydney (LIDA Dog Disease Database)
“Labradoodle – University of Sydney (LIDA Dog Disease Database) & (Nieves 2002
Schnauzer Standard – University of Sydney (LIDA Dog Disease Database)
Wolfhound – University of Sydney (LIDA Dog Disease Database)
Schnoodle – University of Sydney (LIDA Dog Disease Database)
“Labrador Cross – University of Sydney (LIDA Dog Disease Database) & (Nieves 2002
“Great Dane Cross – (LaFond
Schnauzer Standard Cross – University of Sydney (LIDA Dog Disease Database)
Tibetan Mastiff Cross – University of Sydney (LIDA Dog Disease Database)
“Labrador – University of Sydney (LIDA Dog Disease Database) & (Nieves 2002
“Labrador Retriever – University of Sydney (LIDA Dog Disease Database) & (Nieves 2002
“Rottweiler – (Nielen et al. 2001
“St Bernard – (Nielen et al. 2001
“Boxer – (Nieves 2002
“German Shepherd – (Nieves 2002
“Irish Setter – (Nieves 2002
“Alsatian – (Nieves 2002
“Irish Red and White Setter – (Nieves 2002
“Golden Retriever – (LaFond
“Golden Doodle (Groodle) – (LaFond

Disease Author
Dr Merliza Cabriles, Professor of Veterinary Medicine

To learn more about Pyruvate Dehydrogenase Phosphatase 1 Deficiency or any other condition we invite you to search this website. Even better, pick up the phone and call your vet. Your vet knows your pet better than anyone else and is a fountain of information.